The below publications are related to the importance of Cardiac T2*/R2* (iron) on the management of patinets who receive regular blood transfusion. The introduction of cardiac T2*/R2* monitoring in thalassemia major patients has been associated with a dramatic drop in deaths from cardiac disease in the UK. Guidelines [1-3] on the management or iron overload in regularly transfused patients recommend regular monitoring of cardiac T2*/R2* to enable early intervention in cases of cardiac iron overload.
Anderson, L.J., et al., Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. European Heart Journal, 2001. 22(23): p. 2171-2179.
https://pubmed.ncbi.nlm.nih.gov/11913479
Carpenter, J.-P., et al., On T2* Magnetic Resonance and Cardiac Iron. Circulation, 2011. 123(14): p. 1519-1528.
https://pubmed.ncbi.nlm.nih.gov/21444881
Kirk, P., et al., Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major. Circulation, 2009. 120(20): p. 1961-1968.
https://pubmed.ncbi.nlm.nih.gov/19801505
Modell, B., et al., Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. J Cardiovasc Magn Reson, 2008. 10: p. 42.